Research

While research is certainly not a required element of pediatric neurology residency training (several of our graduates elect to enter private practice), there are extensive research opportunities both within the division and throughout the medical school and university for those who desire. Our faculty members are engaged in many different areas of research from imaging to clinical trials to traditional bench research to educational studies.

Washington University prides itself on interdisciplinary collaborations. We have strong research relationships with areas such as radiology, psychology, hematology/oncology, molecular and cell biology, and neuroscience. Within the university are several research institutes with which the department has an extremely close association, including the McDonnell Center for Systems Neuroscience and the Hope Center for Neurological Disorders. During the final year of pediatric neurology training, residents have up to nine months of elective time that they can dedicate to research if they so choose.

2023-2024

Resident	Publication
Afaf Ahmed, MD	Anwar T, Triplett RL, Ahmed A, Glass HC, Shellhaas RA. Treating Seizures and Improving Newborn Outcomes for Infants with Hypoxic-Ischemic Encephalopathy. Clin Perinatol. 2024 Sep;51(3):573-586. doi: 10.1016/j.clp.2024.04.013. Epub 2024 May 22. PMID: 39095097.
Nicholas DeKorver, MD, PhD	DeKorver NW, Zhao W, Butler MR, Di Luca DG, Gurnett C, Nascimento F. An adult with KCNA2-related epilepsy and ataxia. Epileptic Disord. 2024 Apr;26(2):264-266. doi: 10.1002/epd2.20205. Epub 2024 Feb 17. PMID: 38366944.
Saif Sharayah, MD	Virupakshaiah A, Schoeps VA, Race J, Waltz M, Sharayah S, Nasr Z, Moseley CE, Zamvil SS, Gaudioso C, Schuette A, Casper TC, Rose J, Flanagan EP, Rodriguez M, Tillema JM, Chitnis T, Gorman MP, Graves JS, Benson LA, Rensel M, Abrams A, Krupp L, Lotze TE, Aaen G, Wheeler Y, Schreiner T, Waldman A, Chong J, Mar S, Waubant E. Predictors of a relapsing course in myelin oligodendrocyte glycoprotein antibody-associated disease. J Neurol Neurosurg Psychiatry. 2024 Jul 4:jnnp-2024-333464. doi: 10.1136/jnnp-2024-333464. Epub ahead of print. PMID: 38964848.

2022-2023

Resident	Publication
Carley Gilman	Gilman CA, Wusthoff CJ, Guerriero RM. The Role of Electroencephalography in the Prognostication of Clinical Outcomes in Critically Ill Children: A Review. Children (Basel). 2022 Sep 8;9(9):1368. doi: 10.3390/children9091368. PMID: 36138677; PMCID: PMC9497701.
Michelle Lee	Lee MM, McDowell GSV, De Vivo DC, Friedman D, Berkovic SF, Spanou M, Dinopoulos A, Grand K, Sanchez-Lara PA, Allen-Sharpley M, Warman-Chardon J, Solyom A, Levade T, Schuchman EH, Bennett SAL, Dyment DA, Pearson TS. The clinical spectrum of SMA-PME and in vitro normalization of its cellular ceramide profile. Ann Clin Transl Neurol. 2022 Dec;9(12):1941-1952. doi: 10.1002/acn3.51687. Epub 2022 Nov 3. PMID: 36325744; PMCID: PMC9735369.
Gazelle Zerafati-Jahromi	Wongkittichote P, Chhay C, Zerafati-Jahromi G, Weisenberg JL, Mian A, Jensen LT, Grange DK. Novel LIAS variants in a patient with epilepsy and profound developmental disabilities. Mol Genet Metab. 2023 Mar;138(3):107373. doi: 10.1016/j.ymgme.2023.107373. Epub 2023 Jan 7. PMID: 36680912.   Aravamuthan BR, Pearson TS, Ueda K, Miao H, Zerafati-Jahromi G, Gilbert L, Comella C, Perlmutter JS. Determinants of gait dystonia severity in cerebral palsy. Dev Med Child Neurol. 2023 Jul;65(7):968-977. doi: 10.1111/dmcn.15524. Epub 2023 Jan 26. PMID: 36701240; PMCID: PMC10392706.
Rachel Zolno	Gaudioso CM, Zolno R, Wagner A, Mar S. Clinical Reasoning: A 6-Year-Old Girl With Right-Sided Pain and Weakness. Neurology. 2023 Jan 10;100(2):97-102. doi: 10.1212/WNL.0000000000201481. Epub 2022 Oct 18. PMID: 36257712.   Farkas NS, Zolno R, Gaudioso CM, Mian AY, Mar S. Pearls and Oy-sters: MOG-AD Meningoencephalitis with Holocord Gray Matter Predominant Myelitis. Neurology. 2023 Jul 24:10.1212/WNL.0000000000207637. doi: 10.1212/WNL.0000000000207637. Epub ahead of print. PMID: 37487743.

2021-2022

Resident	Publication
Saumel Ahmadi	Xia S, Bozóky Z, Di Paola M, Laselva O, Ahmadi S, Jiang JX, Pitstick AL, Jiang C, Rotin D, Mayhew CN, Jones NL, Bear CE. High-Throughput Functional Analysis of CFTR and Other Apically Localized Proteins in iPSC-Derived Human Intestinal Organoids. Cells. 2021 Dec 4;10(12):3419. doi: 10.3390/cells10123419. PMID: 34943927; PMCID: PMC8699884.
Nicholas DeKorver	DeKorver NW, Chaudoin TR, Zhao G, Wang D, Arikkath J, Bonasera SJ. Complement Component C3 Loss leads to Locomotor Deficits and Altered Cerebellar Internal Granule Cell In Vitro Synaptic Protein Expression in C57BL/6 Mice. Mol Neurobiol. 2021 Nov;58(11):5857-5875. doi: 10.1007/s12035-021-02480-0. Epub 2021 Aug 20. PMID: 34415487.
Laura Gilbert	Gilbert LA, Fehlings DL, Gross P, Kruer MC, Kwan W, Mink JW, Shusterman M, Aravamuthan BR; Cerebral Palsy Research Network Dystonia Study Group. Top 10 Research Themes for Dystonia in Cerebral Palsy: A Community-Driven Research Agenda. Neurology. 2022 Aug 9;99(6):237-245. doi: 10.1212/WNL.0000000000200911. Epub 2022 Jun 17. PMID: 35715199; PMCID: PMC9442618.   Wilson JL, Kim YM, O’Malley JA, Gelineau-Morel R, Gilbert L, Bain JM, Aravamuthan BR. Cerebral Palsy in Child Neurology and Neurodevelopmental Disabilities Training: An Unmet Need. J Child Neurol. 2022 Mar;37(3):194-201. doi: 10.1177/08830738211072711. Epub 2022 Jan 17. PMID: 35037781; PMCID: PMC10392704.

2020-2021

Resident	Publication
Saumel Ahmadi	Leir SH, Yin S, Kerschner JL, Xia S, Ahmadi S, Bear C, Harris A. An organoid model to assay the role of CFTR in the human epididymis epithelium. Cell Tissue Res. 2020 Aug;381(2):327-336. Epub 2020 May 6. [PMID: 32377875]
Cameron Crockett	Gedlinske AM, Stephan CM, Mockler SRH, Laubscher KM, Laubenthal KS, Crockett CD, Zimmerman MB, Mathews KD. Motor outcome measures in patients with FKRP mutations: A longitudinal follow-up. Neurology. 2020 Oct 13;95(15):e2131-e2139. Epub 2020 Aug 6. [PMID: 32764098]
Sarah Dixon	Dixon SM, Binkley MM, Gospe SM Jr, Guerriero RM. Child Neurology Applicants Place Increasing Emphasis on Quality of Life Factors. Pediatr Neurol. 2021 Jan;114:42-46. Epub 2020 Sep 30. [PMID: 33212334]
Maria Galardi	Xu J, Galardi MM, Pok B, Patel KK, Zhao CW, Andrews JP, Singla S, McCafferty CP, Feng L, Musonza ET, Kundishora AJ, Gummadavelli A, Gerrard JL, Laubach M, Schiff ND, Blumenfeld H. Thalamic Stimulation Improves Postictal Cortical Arousal and Behavior. J Neurosci. 2020 Sep 16;40(38):7343-7354. Epub 2020 Aug 21. [PMID: 32826310]Lauzier DC, Galardi MM, Guilliams KP, Goyal MS, Amlie-Lefond C, Hallam DK, Kansagra AP. Pediatric Thrombectomy: Design and Workflow Lessons From Two Experienced Centers. Stroke. 2021 Apr;52(4):1511-1519. Epub 2021 Mar 11. [PMID: 33691502]
Cristina Gaudioso	Gaudioso C, Oo S, Mar S, et al. PedsQL Multiple Sclerosis Module Domain and Item Development: Qualitative Methods. Journal of Child Neurology. 2021 May:8830738211015016. [PMID: 34048290]Gaudioso C, Naismith RT. Optimizing treatment strategies in paediatric, adult and late-onset multiple sclerosis. Brain. 2020 Oct 1;143(10):2866-2868. [PMID: 33103733]Wong GJ, Gaudioso CM, Castro E, Sharifai N, Dahiya S, Dehner LP, Griffith JL. Clinical Reasoning: A 7-year-Old Boy with Acute Onset Altered Mental Status. Neurology. 2021 Apr 13:10.1212/WNL.0000000000012034. Epub ahead of print. [PMID: 33849990]
Laura Gilbert	Aravamuthan BR, Ueda K, Miao H, Gilbert L, Smith SE, Pearson TS. Gait features of dystonia in cerebral palsy. Dev Med Child Neurol. 2021 Jun;63(6):748-754. Epub 2021 Jan 7. [PMID: 33411352]Aravamuthan BR, Fehlings D, Shetty S, Fahey M, Gilbert L, Tilton A, Kruer MC. Variability in Cerebral Palsy Diagnosis. Pediatrics. 2021 Feb;147(2):e2020010066. Epub 2021 Jan 5. [PMID: 33402528]]

2019-2020

Resident	Publication
Jordan Cole	Cole J, Evans E, Mwangi M, Mar S. Acute disseminated encephalomyelitis in children: an updated review based on current diagnostic criteria. Pediatr Neurol. 2019;100:26-34. [PMID: 31371120]
Cameron Crockett	Crockett C, Joshi C, Rosenbaum M, Suneja M. Learning to drive: resident physicians’ perceptions of how attending physicians promote and undermine autonomy. BMC Med Educ. 2019;19(1):293. [PMID: 31366383]
Maria Galardi	Galardi MM, Strahle JM, Skidmore A, Kansagra AP, Guilliams KP. Cerebrovascular complications of pediatric blunt trauma. Pediatr Neurol. 2020;108:5-12. [PMID: 32111560]
Cristina Gaudioso	Gaudioso C, Listernick R, Fisher MJ, et al. Neurofibromatosis 2 in children presenting during the first decade of life. Neurology. 2019;93(10):e964-e967. [PMID: 31363058]
Laura Gilbert	Pearson TS, Gilbert L, Opladen T, et al. AADC deficiency from infancy to adulthood: symptoms and developmental outcome in an international cohort of 63 patients. J Inherit Metab Dis. 2020. Online ahead of print. [PMID: 32369189]
Jasia Mahdi	Mahdi J, Goyal MS, Griffith J, Morris SM, Gutmann DH. Nonoptic pathway tumors in children with neurofibromatosis type 1. Neurology. 2020;95(8):e1052-e1059. [PMID: 32300062]
Elizabeth Wright-Jin	Wright-Jin EC, Gutmann DH. Microglia as dynamic cellular mediators of brain function. Trends Mol Med. 2019;25(11):967-979. [PMID: 31597593]

2018-2019

Resident	Publication
Maria Galardi Cristina Gaudioso	Galardi MM, Gaudioso C, Ahmadi S, Evans E, Gilbert L, Mar S. Differential Diagnosis of Pediatric Multiple Sclerosis. Children (Basel). 2019;6(6):75. Published 2019 Jun 3. [PMID: 31163654]
Jasia Mahdi	Griffith JL, Morris SM, Mahdi J, Goyal MS, Hershey T, Gutmann DH. Increased prevalence of brain tumors classified as T2 hyperintensities in neurofibromatosis 1. Neurol Clin Pract. 2018;8(4):283-291. [PMID: 30140579]
Regina Triplett	Strahle JM, Triplett RL, Alexopoulos D, et al. Impaired hippocampal development and outcomes in very preterm infants with perinatal brain injury. Neuroimage Clin. 2019;22:101787. [PMID: 30991622]
Kimberly Wiltrout	Wiltrout K, Ferrer A, van de Laar I, et al. Variants in DOCK3 cause developmental delay and hypotonia. Eur J Hum Genet. 2019;27(8):1225-1234. [PMID: 30976111]

2017-2018

Resident	Publication
Shannon Agner	Agner SC, Klein RS. Viruses have multiple paths to central nervous system pathology. Curr Opin Neurol. 2018;31(3):313-317. [PMID: 29561519]
Jasia Mahdi	Mahdi J, Shah AC, Sato A, et al. A multi-institutional study of brainstem gliomas in children with neurofibromatosis type 1. Neurology. 2017;88(16):1584-1589. [PMID: 28330960]
Amanda Rogers	Rogers A, Golumbek P, Cellini E, et al. De novo KCNA1 variants in the PVP motif cause infantile epileptic encephalopathy and cognitive impairment similar to recurrent KCNA2 variants. Am J Med Genet A. 2018;176(8):1748-1752. [PMID: 30055040]
Elizabeth Wright-Jin	Avetisyan M, Rood JE, Huerta Lopez S, et al. Muscularis macrophage development in the absence of an enteric nervous system. Proc Natl Acad Sci U S A. 2018;115(18):4696-4701. [PMID: 29666241]

2016-2017

Resident	Publication
Bittu Majmudar	Koelman DL, Benkeser DC, Xu Y, et al. Acute disseminated encephalomyelitis in China, Singapore and Japan: a comparison with the USA. Eur J Neurol. 2017;24(2):391-396. [PMID: 28009079]

2015-2016

Resident	Publication
YoungMin Kim	Ananth AL, Robichaux-Viehoever A, Kim YM, et al. Clinical Course of Six Children With GNAO1 Mutations Causing a Severe and Distinctive Movement Disorder. Pediatr Neurol. 2016;59:81-84. [PMID: 27068059]
Bittu Majmudar	Koelman DL, Chahin S, Mar SS, et al. Acute disseminated encephalomyelitis in 228 patients: A retrospective, multicenter US study. Neurology. 2016;86(22):2085-2093. [PMID: 27164698]
Robert Rudock	Loftspring MC, Landsness E, Wooliscroft L, Rudock R, Jo S, Patel KR. GABAB Encephalitis: A Fifty-Two-Year-Old Man with Seizures, Dysautonomia, and Acute Heart Failure. Case Rep Neurol Med. 2015;2015:812035. [PMID: 26609456]

2014-2015

Resident	Publication
Alexander Fay	Fay AJ, Noetzel MJ, Mar SS. Pediatric Hemorrhagic Brainstem Encephalitis Associated With HHV-7 Infection. Pediatr Neurol. 2015;53(6):523-526. [PMID: 26255752]

2013-2014

Resident	Publication
Merveen Appu	Appu M, Noetzel M. Clinically significant response to zolpidem in disorders of consciousness secondary to anti-N-methyl-D-aspartate receptor encephalitis in a teenager: a case report. Pediatr Neurol. 2014;50(3):262-264. [PMID: 24417935]
Shannon Liang	Kitcharoensakkul M, Schulz CG, Kassel R, et al. Scurvy revealed by difficulty walking: three cases in young children. J Clin Rheumatol. 2014;20(4):224-228. [PMID: 24847751]
Sheel Pathak	Prabhu AM, Pathak S, Khurana D, Legido A, Carvalho K, Valencia I. Nocturnal variant of benign myoclonic epilepsy of infancy: a case series. Epileptic Disord. 2014;16(1):45-49. [PMID: 24691296]
Sheel Pathak	Al-Zubeidi D, Thangarajh M, Pathak S, et al. Fatal human herpesvirus 6-associated encephalitis in two boys with underlying POLG mitochondrial disorders. Pediatr Neurol. 2014;51(3):448-452. [PMID 25160553]

2012-2013

Resident	Publication
Jacqueline Anderson	Mills KI, Anderson J, Levy PT, et al. Duplication of 20p12.3 associated with familial Wolff-Parkinson-White syndrome. Am J Med Genet A. 2013;161A(1):137-144. [PMID: 23239491]
Jacqueline Anderson	Anderson JL, Levy PT, Leonard KB, Smyser CD, Tychsen L, Cole FS. Congenital lymphocytic choriomeningitis virus: when to consider the diagnosis. J Child Neurol. 2014;29(6):837-842. [PMID: 23666045]
Nico Dosenbach	Fair DA, Nigg JT, Iyer S, et al. Distinct neural signatures detected for ADHD subtypes after controlling for micro-movements in resting state functional connectivity MRI data. Front Syst Neurosci. 2013;6:80. Published 2013 Feb 4. [PMID: 23382713]
Alexander Fay	Fay AJ, Mowry EM, Strober J, Waubant E. Relapse severity and recovery in early pediatric multiple sclerosis. Mult Scler. 2012;18(7):1008-1012. [PMID: 22183939]
Swati Karmarkar	Saini A, Karmarkar SA, Rongkavilit C, et al. Index of suspicion. Pediatr Rev. 2013;34(1):41-46. [PMID: 23281361]
Katharine Meddles	Hogeling M, Meddles K, Berk DR, et al. Extensive subcutaneous fat necrosis of the newborn associated with therapeutic hypothermia. Pediatr Dermatol. 2012;29(1):59-63. [PMID: 21906137]
Adam Ostendorf	Myshrall TD, Moore SA, Ostendorf AP, et al. Dystroglycan on radial glia end feet is required for pial basement membrane integrity and columnar organization of the developing cerebral cortex. J Neuropathol Exp Neurol. 2012;71(12):1047-1063. [PMID: 23147502]
Adam Ostendorf	Ostendorf AP, McKinstry RC, Shimony JS, Gutmann DH. Teaching NeuroImages: T2 hyperintensities in neurofibromatosis type 1. Neurology. 2013;80(20):e215-e216. [PMID: 23671349]